Aim: The aim of the study was to employ cumin oil in the synthesis of silver nanoparticles and check the antioxidant activity of the cumin oil mediated silver nanoparticles. Background: The introduction of Nanoparticles (NPs) has revolutionized every field including medicine, nutrition and energy. The use of nanotechnology in medicine especially for drug delivery is shown to have various benefits. Nanoparticles are being used to reduce toxicity and side effects that drugs may impose to the patient. Cumin (Cuminum cyminum) is a common spice used for its distinct aromatic effect. Plant mediated biological synthesis of nanoparticles has been gaining importance due to its simplicity and eco friendliness. This study therefore was aimed to synthesize cumin oil mediated silver nanoparticles and assess its antioxidant activity. Materials and Methods: Cumin oil mediated silver nanoparticles were initially synthesised and characterised by UV-Visible spectrophotometer and TEM. Further the cumin oil mediated AgNPs were subjected to DPPH assay to determine the antioxidant activity. Results: Cumin oil mediated AgNPs were biosynthesised with ease and showed good antioxidant activity compared to standard. Conclusion: This study conclude that cumin seed oil mediated silver nanoparticles have the potential to be used as an effective antioxidant. Hence, it may be employed in large scale production and may be used in many medicinal applications where there is a need for antioxidant.

The aim of this study was to systematically review the use of medicinal plants for the treatment of varicose ulcers. The databases used in the search were: Medline/Pubmed, Scopus, Cinhal, Lilacs and Web of Science. The selection process was divided into two phases: the reading of titles and abstracts and the full reading of selected articles. The item description was compared with the checklist of the Consolidated Standards of Reporting Trials. The initial search produced 3505 articles and seven were selected for inclusion in the systematic review. Of the included studies, 7 (100%) evaluated the reduction of the ulcer area, 4 (57·14%) evaluated reepithelisation, 2 (28·57%) evaluated bacterial flora and 1 (14·28%) evaluated the oxygen pressure and percutaneous carbon dioxide. The level of evidence rating indicated that five studies (71·42%) were rated at level 2 and two (28·57%) were rated at level 3. The quality assessment was performed using the Jadad scale, which is prevalent in the literature. The quality score of the Jadad questionnaire ranges from 0 to 5; here, the studies analysed had an average of 2·5. A meta-analysis was performed on two studies that analysed the effects of Mimosa tenuiflora hydrogel in the treatment of venous ulcer and included 42 patients with a mean age of 60·5 years and a mean duration of treatment of 10·5 weeks. Heterogeneity was assessed using I ; we obtained a high value of 84%. We concluded that, despite the efficacy of the incorporation of Ageratina pichinchensis into the gel, the hydrogel that incorporated M. tenuiflora appeared to be a promising candidate for the management of venous ulcers.

Os antimicrobianos são fármacos que agem inibindo o crescimento ou a morte de microrganismos, sendo a segunda classe de medicamentos mais prescrita em hospitais e responsável por 20 a 50% das despesas hospitalares com medicamentos. Este estudo teve como objetivo analisar o perfil das prescrições de antimicrobianos de uso restrito em uma Unidade de Terapia Intensiva. Trata-se de um estudo farmacoepidemiológico descritivo de delineamento transversal, com abordagem quantitativa de análise estatística de dados secundários do setor de Farmácia do Hospital Universitário de Lagarto/SE (HUL), entre os meses de janeiro a dezembro de 2019, aprovado pelo Comitê de Ética e Pesquisa da Instituição preponente Faculdade AGES (Número do parecer: 3.758.862). Das 329 solicitações de antimicrobianos de uso restrito referentes ao ano de 2019, 41,51 % dos eram pacientes idosos, 52,83 % do sexo masculino, 26,75% com diagnósticos de sepse e 23,40% com problemas do trato respiratório. O uso do Carbapenêmico Meropenem (35,56 %), o glicopeptídeos Vancomicina (20,67%) e a Piperacilina + Tazobactam (19,77%) foram os medicamentos mais prescritos. Esse resultado pode ser explicado pelo fato de serem antimicrobianos de amplo espectro, utilizado inicialmente como terapia empírica em situações consideradas graves, e depois mantido como meio de se ter mais segurança e uma ampla efetividade contra diversos microrganismos. Subsidiar indicadores epidemiológicos que podem ser utilizados para a melhoria da assistência à saúde, pode proporcionar a eficácia de tratamentos propostos, além de nortear sobre pontos que necessitam de ajuste no fluxo de prescrição e liberação de tais medicamentos.

Ethical approval for the study Ethical approval for this ethnopharmacological survey was obtained from the Ethics and Research Committee of the University Hospital of Sergipe (CAE: 61094816.6.0000.5546). The participants were adequately informed about the nature of study, and benefits and risks involved. The subjects who agreed to participate of the study signed a written consent document. Characterization of Brazilian health care Ever since 1988, the Brazilian Constitution has promised free public healthcare in all complexity levels through the SUS, founded by taxes and social contributions. The SUS, by means of FHS, has decentralized care coverage and proved to reduce common diseases, mortality rate, and unnecessary admissions. 7 Alive pharmacy The alive pharmacy presents in the health units constitute medicinal gardens where are carried out activities such as cultivation, processing and management of medicinal plants, ensuring their correct and safe use in basic care.