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-903 Ribeirão Preto -SP, BrasilRecebido em 1/9/06; aceito em 25/5/07; publicado na web em 3/12/07This work describes the isolation and structural determination of pharmacological compounds present in the bark of roots of Tabernaemontana catharinensis (Apocynaceae). Among the 27 substances detected 12 were identified as terpenoid-indole alkaloids, 2 steroids and 13 pentacyclic triterpenes. Structures were outlined based on HMQC, COSY, DEPT, 13 C, and 1 H NMR data and MS. Spectral data of indole alkaloids were reviewed. An in vitro screening of the extracts and isolated compounds was carried out. Compounds ibogamine (5), 3-oxo-coronaridine (9) and 12-methoxy-4-methylvoachalotine (MMV) demonstrated effective cytotoxicity towards SKBR-3 breast adenocarcinoma and C-8161 human melanoma tumor cell lines.

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The prevalence of design problems may cause re-engineering or even discontinuation of the system. Due to missing, informal or outdated design documentation, developers often have to rely on the source code to identify design problems. Therefore, developers have to analyze different symptoms that manifest in several code elements, which may quickly turn into a complex task. Although researchers have been investigating techniques to help developers in identifying design problems, there is little knowledge on how developers actually proceed to identify design problems. In order to tackle this problem, we conducted a multi-trial industrial experiment with professionals from 5 software companies to build a grounded theory. The resulting theory offers explanations on how developers identify design problems in practice. For instance, it reveals the characteristics of symptoms that developers consider helpful. Moreover, developers often combine different types of symptoms to identify a single design problem. This knowledge serves as a basis to further understand the phenomena and advance towards more effective identification techniques.