The availability of NPK compound fertilizer is expected to help farmers to optimally supply the nutrient needs of corn plants. The aim of the study was to determine the efficient dose of NPK 15-15-6-4 fertilizer and its combination with urea on the growth and yield of corn. The study was conducted in Simbang Village, Simbang District, Maros Regency, South Sulawesi in January - April 2019. The study used a Randomized Complete Block Design (RCBD) with a combination of 7 treatments with four replications, consisting of: (P1) 400 kg NPK 15-15-6-4; (P2) 400 kg NPK 15-15-6-4 + 100 kg urea; (P3) 400 kg NPK 15-15-6-4 + 150 kg urea; (P4) 450 kg NPK 15-15-6-4; (P5) 350 kg NPK 15-15-6-4; (P6) 350 kg NPK 15- 15-6-4+ 150 kg urea; (P7) 150 kg NPK Phonska + 250 kg urea. The results showed that NPK 15-15-6-4 compound fertilizer had a good effect on the growth and yield of corn plants. NPK 15-15-6-4 compound fertilizer at a dose of 450 kg/ha and a dose of 400 kg NPK 15-15-6-4 + 100 kg urea gave the best effect with total yield up to 5.5-5.9 ton/ha.