Common vetch, Vicia sativa L, is an annual grain legume species and a member of the Vicieae tribe. Generally grown as a mix for hay production or grazing, vetch has considerable potential as a grain and forage legume as the seed contains high protein levels. Although the seed has also been used for human consumption, several common accessions contain β‐cyanolalanine and its γ‐glutamyl peptide derivative, which are neurotoxic to monogastric animals. Traditional breeding methods reduced seed toxin levels from 1.15% to between 0.3% and 0.4% of total seed protein, however, due to accumulative effects, much lower or zero levels are required to ensure safe consumption. This may ultimately be achieved through either blocking the neurotoxin production upstream or enabling the currently inactivated downstream biosynthesis of asparagine. Both approaches require the development of a robust and efficient transgenic and regeneration system. The initial steps toward the development of these systems are outlined in this chapter. A regeneration system was developed using somatic embryonic callus derived from epicotyl regions of etiolated seedlings. An Agrobacterium ‐mediated transformation system was also developed, again with best results from using epicotyl‐derived callus.