Stres akademik menjadi permasalahan yang banyak terjadi pada mahasiswa. Berbagai penyesuaian yang harus dihadapinya dalam peran dan lingkungan barunya tersebut kerapkali menjadi stressor tersendiri, terlebih bagi mahasiswa yang tidak memiliki kemampuan koping yang adaptif. Penelitian ini bertujuan untuk melihat pengaruh program pelatihan strategi koping fokus emosi untuk menurunkan tingkat stres akademik pada mahasiswa. Desain studi menggunakan metode eksperimen quasi dengan one group pretest–posttest design. Subjek dalam penelitian berjumlah 16 mahasiswa (M=19,81 tahun; SD=0,911) dari salah satu perguruan tinggi di Yogyakarta, Indonesia. Instrumen pengukuran yang digunakan meliputi Skala Koping Fokus Emosi dan Skala Stres Akademik. Analisis statistik paired sample t-test menunjukkan bahwa pelatihan strategi koping fokus emosi terbukti dapat menurunkan stres akademik pada mahasiswa dengan t(15)=2,149; p=0,048 (p<0,05). Hasil penelitian ini diharapkan dapat dijadikan sebagai referensi intervensi bagi program kesehatan mental di perguruan tinggi.

IMSC transplantation during CABG is considered one of the most promising methods to effectively deliver stem cells and has been widely studied in many trials. But the results of outcomes and safety of this modality still vary widely. We conducted this meta-analysis of randomized controlled trials (RCTs) to evaluate not only the outcome but also the safety of this promising method. A meta-analysis was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. A comprehensive literature search was undertaken using the PubMed, Scopus, and Cochrane databases. Articles were thoroughly evaluated and analyzed. Twenty publications about IMSC during CABG were included. Primary outcomes were measured using LVEF, LVESV, LVESVI, LVESD, LVEDV, LVEDVI, LVEDD, WMSI, and 6-MWT. Safety measures were depicted by total deaths, MACE, CRD, CVA, myocardial infarction, ventricular arrhythmia, and cardiac-related readmission. IMSC transplantation during CABG significantly improved LVEF (MD = 3.89%; 95% CI = 1.31% to 6.46%; p = 0.003) and WMSI (MD = 0.28; 95% CI = 0.01–0.56; p = 0.04). Most of the other outcomes showed favorable results for the IMSC group but were not statistically significant. The safety analysis also showed no significant risk difference for IMSC transplantation compared to CABG alone. IMSC during CABG can safely improve cardiac function and tend to improve cardiac volumes and dimensions. The analysis and application of influencing factors that increase patients’ responses to IMSC transplantation are important to achieve long-term improvement.

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Background Essential thrombocytosis (ET) is a myeloproliferative neoplasm characterized by increased platelet counts and excessive large and morphologically mature megakaryocytes in the bone marrow. ET may be complicated by thrombotic events, mostly in small and medium vessel. However there are limited evidence to guide management, particularly in cases with acute tissue ischemia. Understanding the basic pathophysiology concept of thrombosis in patient with ET is vital in choosing the right modality for revascularization. Case Summary A 73-year-old female with history of essential thrombocytosis presenting with severe debilitating pain on her right lower extremity. Physical examination showed decreased peripheral oxygen saturation. Dupplex Ultrasound revealed total thrombus at femoral artery dextra and no flow at popliteal artery, anterior and posterior tibial artery. We decided to perform revascularization with percutaneous mechanical thrombectomy (Angiojet). Arteriography evaluation still showing abundant number of thrombus. We continued with manual aspiration using guiding catheter and showing a remarkable result with normal blood flow down to the distal part with minimal residual thrombus. Discussion Histopatbological evaluations of arterial thrombi in ET revealed platelet-rich clots with abundant von Willebrand factor (VWF) and very little fibrin. Hence tllrombolysis agent used in CDT will not effective. Large thrombus which can not be lysed by fibrinolytic should be evacuated by a larger hole catheter aspiration