Background: Hemodynamic instability of patients during induction of anesthesia and intubation, are very important clinical concern. Hemodynamic change after induction of general anesthesia is a common event and associated with negative result in clinical practice.Methodology: An institutional based observational prospective cohort study was conducted from February 26 up to April 30. The source of population, all adult patients age between 18-60 years old, underwent abdominal surgery under general anesthesia in Wolaita Sodo Teaching and Referral Hospital during the study period. We checked data manually for completeness and then coded and entered into the epi data version and export to SPSS statistical package program (Version 25) for further analysis. Normality of variables was measure using the Shapiro-Wilk test. Differences of numerical data between groups were evaluated using student's t-test and Mann-Whitney U-test. A p value of < 0.05 consider as statically significant.Result: Mean arterial pressure was significantly increased immediately after induction of anesthesia, in the ketamine group compared with ketamine+ thiopental (P < 0.003). Heart rate was significantly rise in ketamine group during induction of anesthesia (maximum 96.42 ± 13.08) (P < 0.05). The maximum Systolic blood pressure change is observed after intubation in ketamine group 133.42 ± 12.04 while all Diastolic blood pressure was significantly different from baseline at post induction and intubation, 5 min and 10min in both group, (P value 0.001,0.005, 0.000, and 0.008 respectively) higher DBP (79.82 ± 10.36) was measured immediately after induction of anesthesia in ketamine group l measurement time drop in ketamine-thiopental group. Conclusion:In conclusion, the use of a combination of the drug with ketamine has a better hemodynamic stability effect than using a single (ketamine or thiopental) induction agent.