Polyvinylpyrrolidone (PVP) and tannic acid (TAN) macromolecules were attached to polymethyl methacrylate (PMMA) surface in a two-step approach in order to establish a tailored tissue-friendly surface layer. First PMMA surface was activated by an air diffuse coplanar surface barrier discharge plasma and subsequently coated with these macromolecules. PVP and TAN which has antibacterial effects are widely used in food and drug industry, however have never applied for polymer surface modification. Throughout characterization measurements confirm that during plasma treatment oxygen containing functional groups (-OH, -C=O, -COOH) incorporate in the surface. 1HNMR spectroscopy verified the strong H-bonds between PVP and TAN, which rendered the layer-by-layer as- Many researches have been carried out to overcome this shortcoming of polymers including PMMA.A common approach to make the surface more hydrophilic is to modify the surface chemistry. Due to the chemical inertness of the polymeric materials their surface modification means that first they shall undergo surface activation before subsequent covalent functionalisation (Fig.1.). It was found that a hydrophilic surface created by surface modification and formation of new functional groups on the surface by oxygen plasma treatment greatly inhibited bacterial adhesion to PMMA surface [8].The hydrophilic properties, however, usually does not last long due to the ageing effect of such treatment [9]. The speed of ageing is affected by several operating factors of the treatment, includ-
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