Despite the increasing use of online health literacy resources, scholars and practitioners assess Web sites based on readability measures such as sentence length, word choice, and other ''print-centric'' features to the exclusion of features unique to online media. In this article, we offer an alternative approach that accounts for multiple modes of communication and non-linear arrangement-features that characterize online media. To demonstrate this approach, we detail a recent project to redesign a cancer patient web portal. Included in our discussion of the project is a heuristic tool for designing web navigation as well as detailed examples of reworded content.