BACKGROUND People aged 65 and over are more likely to have health problems related to aging, polypharmacy, and low treatment adherence. Moreover, health literacy levels decrease with increasing age. OBJECTIVE To assess an app’s utility in promoting health literacy in people aged 65 and over. METHODS A multidisciplinary team of professionals has developed a simple, intuitive, and video-based app (DigiAdherence) with recipes, nutritional counseling, physical activity, cognitive exercise, motivation to adhere to treatment, falls' prevention, and health literacy content. A total of 25 seniors attending the Personalized Health Care Unit of Portimão or the Family Health Unit of Portas do Arade (ACeS Algarve II - Barlavento, ARS Algarve, Portugal), will be recruited. Subjects must have 65 years of age or more, own a smartphone or tablet, and be willing and consent to participate. Those who do not know how to use or do not have a smartphone/tablet will be excluded. Likewise, people with major cognitive or physical impairment as well as living in a long-term care center will also not be included in this study. Participants will have access to the application for 4 weeks and will be evaluated at 3 different timepoints. Participants will be asked about the app’s utility, expectations (before access to the app), satisfaction (after access to the app), and benefits for their health. Subjects will be assessed in a clinical interview with a semi-structured questionnaire, including questions of users’ experience, satisfaction, app’s utility, quality of life, treatment adherence and lifestyles. RESULTS This study is expected to start recruiting before mid-2021. CONCLUSIONS Since the next generation of elderly is quite digitized, information and communication technologies could potentially be used as a health literacy tool to improve lifestyles among seniors.