This case study is about finding the best fluoropolymer coating for pipes that resists the sodium hypochlorite continue production, which is one of the most aggressive chemical processes that can lead to molecular attack in reactors made by lined pipes. There are several types of coatings pipe such as fiberglass, polymers and elastomers, but the fluoropolymers which have unique properties that make them resistant to chemical attack. In this production process, the premature deterioration of coating pipes is common, due to the expansion of chlorine at the inlet of the reactor, caused by the reaction of chlorine–sodium hydroxide, this is the critical point of the process. Some problems that we find is the chemical attack in that some fluoropolymers coating suffer premature degradation caused by the chemical compatibility, in this case, we explain in detail the chemical and molecular composition of each of the fluoropolymers and how this change occurs at the molecular level. While the lined pipes are the best economical option for chemicals applications, however, it is important to know the correct coating to ensure a long lifetime and avoid piping changes due to premature degradation. Based on the findings of the chemical resistance of each fluoropolymer under study, it is determined which is the best fluoropolymer that resists continuous production of sodium hypochlorite. Results were obtained by a systematic review of the literature.