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Introduction: Data on hepatopancreatobiliary (HPB) surgery and COVID-19 are scarce. The objective of the study was to determine the outcomes HPB procedures during the COVID-19 pandemic and compare results to the previous year. Methods: IRB approved study of HPB procedures (April, 2020-November, 2020. Primary endpoints: Thirty-day surgical morbidity/mortality, including COVID-19 infection. Secondary endpoints: Comparison between 2019 and 2020 procedures. Results: Twenty-five patients were included. In 2020, HPB procedures decreased 31.6%. About 60% developed complications (Clavien-Dindo Grade III, 20%). Three patients developed post-operative COVID-19 infection (two deaths: 66% COVID-19 mortality). When compared to the previous year, there were more emergency cases, ventilator-assisted patients (p < 0.05) and pre-operative acute renal failure (p = 0.06). Clavien-Dindo complication grades were higher in 2020. Thirty-day mortality was also higher (16% vs. 5.6%). Conclusion: HPB surgical activity was negatively influenced by COVID-19 on 30-day morbidity/mortality. HPB patients who developed post-operative COVID-19 infection had a complicated course with significant mortality.

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Introducción: Los síntomas gastrointestinales son uno de los efectos posteriores al trasplante y parecen relacionarse a múltiples factores. El objetivo del estudio fue determinar la prevalencia de síntomas gastrointestinales en una cohorte mexicana de receptores de trasplante renal y su probable asociación al régimen inmunosupresor. Material y métodos: Se encuestó a pacientes receptores de trasplante renal mayores de 18 años, con función renal y tratamiento inmunosupresor de febrero a mayo de 2019. Los síntomas gastrointestinales fueron evaluados mediante el cuestionario Gastrointestinal Symptom Rating Scale (GSRS). Las puntuaciones totales más altas indican mayor severidad en los síntomas. Se evaluaron las diferencias en la puntuación GSRS tanto total como por síntoma específico. Se consideró una p < 0.05 como estadísticamente significativa. Resultados: Se encuestaron 103 pacientes (masculinos, 63.15%), edad promedio 36.6 años, tiempo promedio postrasplante 45.5 meses. De los pacientes, 92 (91%) tuvieron un síntoma gastrointestinal. Los síntomas más comunes fueron dolor de apetito (65%), eructos (49.5%) y heces sueltas (42.7%). Los pacientes femeninos tuvieron mayor puntuación GSRS que los masculinos (p < 0.05). La hemoglobina tuvo una ABSTRACT Introduction: Gastrointestinal symptoms are post-transplant side effects that appear to be related to multiple factors. The objective of the study was to determine the prevalence of gastrointestinal symptoms in a Mexican cohort of renal transplant recipients and their possible association with the immunosuppressive regimen. Material and methods: Renal transplant recipients older than 18 years of age with stable renal function were interviewed from 02/2019-05/2019. Gastrointestinal symptoms were evaluated using the Gastrointestinal Symptom Rating Scale (GSRS) questionnaire. Higher total scores indicate increased severity in symptoms. Differences in GSRS score were assessed for both total and specific symptom. A < 0.05 p was considered statistically significant. Results: 103 patients (male, 63.15%) were surveyed, average age 36.6 years, average post-transplant time 45.5 months. Ninety-two patients (91%) had a gastrointestinal symptom. The most common symptoms were hunger pain (65%), belching (49.5%) loose stools (42.7%). Female patients had a higher GSRS score than males (p < 0.05). Hemoglobin had a significant inverse correlation to the GSRS score (p < 0.05). Individual symptom analysis showed reverse