A three-month-old male entire Bouvier des Flandres was presented for acute onset dysuria, haematuria, lethargy and severe pain on palpation of the penis. Further investigation revealed a parcellar fracture of the cranial separate ossification centre of the os penis and associated urinary tract infection with presumed pyelonephritis. Fluoroscopic retrograde urethrography was performed revealing intermittent urethral obstruction caused by displacement of the cranial bone fragment of the separate ossification centre of the os penis. The urethra was catheterised to realign the fragments and to permit urination and antibiotic treatment was started. The urinary catheter was kept in place for five days. After its removal, normal urination was observed with complete resolution of the clinical signs. Follow-up radiographs and ultrasound examination confirmed resolution of mechanical obstruction with fusion of part of the separate ossification centre and realignment of the displaced bony fragment.
Background Information regarding serum insulin concentration in dogs newly diagnosed with insulinoma and its association with clinical stage and survival time is lacking. Objective Examine association between serum insulin concentration and survival and clinical disease stage in dogs with insulinoma. Animals. Fifty‐nine client‐owned dogs with a diagnosis of insulinoma from 2 referral hospitals. Method Retrospective observational study. The χ2 test was used to compare the proportion of dogs with increased insulin concentration in groups with or without metastasis at the time of diagnosis. Linear mixed‐effect models were built to compare differences in insulin concentration between dogs with and without evidence of metastasis at the time of original diagnosis. Cox's proportional hazards regression and Kaplan‐Meier graphs were used to evaluate the association between insulin concentration and insulin groups and survival. Results Median serum insulin concentration was 33 mIU/L (range, 8‐200 mIU/L) in dogs with World Health Organization (WHO) stage I disease and 45 mIU/L (range, 12‐213 mIU/L) in dogs with WHO stage II and III disease. No difference was found in the proportion of dogs with increased insulin concentration with or without metastasis (P = .09). No association was identified between insulin concentration and survival (P = .63), and between dogs grouped by insulin concentration and survival (P = .51). Conclusions and Clinical Importance Serum insulin concentrations were not different between dogs with or without metastasis at diagnosis. The degree of insulinemia does not provide further information regarding the stage of the disease and is not associated with survival time in dogs with insulinoma.
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