PA-IA is a rational, effective, and safe adjuvant therapy for severe pemphigus and warrants wider use for this indication. A controlled study should compare side-effects and effectiveness of PA-IA with other treatment options for pemphigus.

Patients with relapsed malignant glioma have a poor prognosis. We developed a strategy of vaccination using autologous mature dendritic cells loaded with autologous tumour homogenate. In total, 12 patients with a median age of 36 years (range: 11 -78) were treated. All had relapsing malignant glioma. After surgery, vaccines were given at weeks 1 and 3, and later every 4 weeks. A median of 5 (range: 2 -7) vaccines was given. There were no serious adverse events except in one patient with gross residual tumour prior to vaccination, who repetitively developed vaccine-related peritumoral oedema. Minor toxicities were recorded in four out of 12 patients. In six patients with postoperative residual tumour, vaccination induced one stable disease during 8 weeks, and one partial response. Two of six patients with complete resection are in CCR for 3 years. Tumour vaccination for patients with relapsed malignant glioma is feasible and likely beneficial for patients with minimal residual tumour burden.

Over the past decades, electrospray ionization for mass spectrometry (ESI-MS) has become one of the most commonly employed techniques in analytical chemistry, mainly due to its broad applicability to polar and semipolar compounds and the superior selectivity which is achieved in combination with high resolution separation techniques. However, responsiveness of an analytical method also determines its suitability for the quantitation of chemical compounds; and in electrospray ionization for mass spectrometry, it can vary significantly among different analytes with identical solution concentrations. Therefore, we investigated the ESI-response behavior of 56 nitrogen-containing compounds including aromatic amines and pyridines, two compound classes of high importance to both, synthetic organic chemistry as well as to pharmaceutical sciences. These compounds are increasingly analyzed employing ESI mass spectrometry detection due to their polar, basic character. Signal intensities of the peaks from the protonated molecular ion (MH+) were acquired under different conditions and related to compound properties such as basicity, polarity, volatility and molecular size exploring their quantitative impact on ionization efficiency. As a result, we found that though solution basicity of a compound is the main factor initially determining the ESI response of the protonated molecular ion, other factors such as polarity and vaporability become more important under acidic solvent conditions and may nearly outweigh the importance of basicity under these conditions. Moreover, we show that different molecular descriptors may become important when using different types of instruments for such investigations, a fact not detailed so far in the available literature.

A novel combination of several experimental and non-experimental paradigms was applied to explore initial stages of incidental vocabulary acquisition (IVA) during reading in German as a second language (L2). The results show that syntactic complexity of the context positively affects incidental acquisition of new words, triggering the learner's shift of attention from the text level to the word level. A subsequent semantic priming task revealed that the new words establish associations with semantically related representations in the L2 mental lexicon after just three previous occurrences and without any consolidation period. The semantic inhibition effect for the new words (contrary to semantic facilitation for known L2 words), however, indicates that the memory traces of the new semantic representation are still very weak and that their retrieval is probably hindered by stronger semantically related representations that have much lower activation thresholds and higher potential for being selected.

In 2 picture-naming and 2 grammaticality judgment experiments, the authors explored how the phonological form of a word, especially its termination, affects gender processing by monolinguals and unbalanced bilinguals speaking German. The results of the 2 experiments with native German speakers yielded no significant differences: The reaction times were statistically identical for items from gender typical, ambiguous, and gender atypical groups. The 2 experiments with English bilinguals who had learned German as a second language (L2), however, provided evidence that the L2 word's termination plays a role in L2 gender processing. Participants were fastest when producing gender-marked noun phrases containing a noun with a gender typical termination and slowest when the noun had a gender atypical termination. Analogous results were obtained in the grammaticality judgment experiment. These findings support the assumption that there is interaction between the levels of phonological encoding and grammatical encoding at least in bilingual processing.