Furo [2',3':4,5]pyrrolo [1,2-d][1,2,4]triazin-8(7H)-ones 5 were synthesized either by reaction of carbohydrazide 2 with triethyl orthoesters or by acetylation of methyl 4H-furo[3,2-b]pyrrole-5-carboxylate 1 followed by thionation of 4-acetylfuro[3,2-b]pyrrole-5-carboxylate 3 and cyclisation of thione 4 with hydrazine. Triazine 5a afforded the corresponding thione 7 by reaction with P2S5. Upon reaction with alkyl-or acylhalogenides compounds 5 and 7 gave N(7)-substituted products 6 and 8, respectively. Finally, triazino-triazinone derivative 9 was synthesized by cyclisation of thione 8b with hydrazine. Compounds 5 -9 were evaluated for their antibacterial activity.

Hydrazinolysis of bis-esters led to bis-carbohydrazides which subsequently cyclized in acetic acid under microwave irradiation to form either pyrazine or acetamide derivatives with unusual chirality. Prepared compounds were evaluated for their antibacterial activity on Escherichia coli and Micrococcus luteus.