Delayed mandible reconstruction is a challenged situation in Oral and Maxillofacial surgery, due to great quantity of fibrous tissue and quality of covering soft tissue. The virtual surgical planning not only assists in previewing results, it assists in adjust the size and format of bone grafts by means of cutting surgical guides according to the anatomy of regional donor area too. We reported a clinical case a 20-years-old male patient attended to our service presented with segmented mandibular defect. Aiming to perform the procedure with more predictability, accuracy and less morbidity, we planned to remove the anterior portion of the iliac crest bone using a cutting guide computer aided design/computer aided manufacturing which was in accordance with the curvature and the size mandible bone defect.