Background: The prevalence of Diabetes mellitus in the countries of Central and South America was estimated at 27.4 million people and considered for 45 million in 2030. In Brazil, Diabetes mellitus in the population above 18 years increased from 5.3 % to 5.6 % between 2009 and 2016. Objective: was to present the main findings of the relation of periodontal diseases and diabetes mellitus through a systematic review. Discussion: Dental treatment in diabetic patients can be carried out according to their glycemic condition. Almost all patients need to be anesthetized, and diabetic patients are no different, when we use local anesthetics with epinephrine 1: 100,000 are well tolerated. However, epinephrine has pharmacological effect opposite to that of insulin, glucose can therefore increase with use. Must be used with caution epinephrine in hypertensive diabetic patients who have suffered myocardial infarction or who have cardiac arrhythmias. Conclusion: According to literary findings, it is imperative to control Diabetes mellitus, because it is a strong predictor and enhancer of periodontal diseases, and prior to more severe surgical procedures and to apply minimally invasive treatments in these patients.
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