Hohe Antitumor‐Aktivität zeigt das erste sterisch gehinderte (nichtplanare), perhalogenierte Zink‐Phthalocyanin (Pc), [F64PcZn(Aceton)2], im Vergleich zu planarem Zinkperfluorphthalocyanin (siehe Struktur: F grün, N blau, O rot, C grau). Die Perfluorisopropyl‐Substituenten erhöhen die Löslichkeit, stabilisieren die axialen Liganden (wie die koordinierten Acetonmoleküle in der abgebildeten Struktur), verkleinern die HOMO‐LUMO‐Lücke, verändern die Redoxpotentiale und verlängern die Lebenszeit des angeregten Triplettzustandes des neuen Komplexes.

An incompressible sphere with a vanishing thermal expansivity suspended in a fluid can generate a photoacoustic effect when the heat deposited in the sphere by a light beam diffuses into the surrounding liquid causing it to expand and launch a sound wave. The properties of the photoacoustic effect for the sphere are found using a Green's function solution to the wave equation for pressure with Neumann boundary conditions. The results of the calculation show that the acoustic wave for fast heat liberation is an outgoing compressive pulse followed by a reflected pulse whose time profile is modified as a result of frequency dependent reflection from the sphere. For slow heat release by the sphere, the photoacoustic effect is shown to be proportional to the first time derivative of the heat flux at the particle-fluid interface.

The diffracted-light signals produced in transient grating experiments by phthalocyanine dyes, candidates for photodynamic therapy agents, are shown to be strongly dependent on the presence of oxygen in solution. Data indicate a facile transfer of energy from the excited dye to oxygen in solution to form excited 1Δg oxygen. The efficiency of excited-oxygen production can be determined by recording the thermal mode of wave motion in a transient grating experiment. The triplet-state lifetimes and quantum efficiencies for the formation of 1Δg oxygen determined from the experiments are found to depend on structural details of the dyes, which can be rationalized by considering π-orbital interactions. The salient features of the transient grating method for evaluating type II photodynamic therapy agents are that the method requires no chemical species to be added to the dye solution that complicate the photochemistry and that the method is sensitive enough that experiments can be carried out at micromolar concentrations.