The risk of nest depredation is influenced by numerous factors, including predator density, environmental conditions of the nesting landscape, and nesting behaviors of mothers. Many reptiles choose nest microhabitats that facilitate embryonic development, but little is known about how the risk of nest depredation in different habitats influences egg survival and nesting behavior. To address this knowledge gap, we quantified predator-prey relationships between square-back marsh crabs (Armases cinereum) and eggs of the brown anole lizard (Anolis sagrei). Our experiments aimed to answer the following questions: (1) are marsh crabs a predator of brown anole eggs, (2) does egg depredation differ among microhabitat types, and (3) how does crab density affect egg survival? We placed viable eggs in three different microhabitats used by nesting females (open area, palm frond, leaf litter), and manipulated the placement of the eggs as either buried or not buried. We also manipulated crab density in a field experiment. Our experiments confirmed square-back marsh crabs as egg predators, and eggs in the leaf litter or eggs buried were the least likely to be depredated. Additionally, eggs in leaf litter and under palm fronds escaped depredation longer than those in the open. Increased crab density also raised the risk of depredation for eggs placed under palm fronds or in open habitats. These results suggest that selection of nest sites by female brown anoles can influence offspring survival in the presence of marsh crabs, and the importance of nest site microhabitat choice may vary with predator density.