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This article is intended solely for the personal use of the individual user and is not to be disseminated broadly. same acute pharmacological and subjective effects of alcohol and cannabis as males, after smoking less cannabis, which has potential implications for informing education and policy. Further research is warranted on sex differences in cannabis pharmacology, as well as the combined effects of alcohol and cannabis. Public Health Significance StatementDespite the highly prevalent co-use of alcohol and cannabis, particularly among young adults, sex differences in the pharmacological and subjective effects of co-use are not well understood. In a sample of regular alcohol and cannabis users, females experienced the same acute effects of alcohol and cannabis as males, after smoking significantly less cannabis. These findings may suggest sex differences in how males and females co-use alcohol and cannabis and experience their effects, which have potential important implications for informing education and policy.