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The digital era is introducing technological innovations that create valuable data resources and provide opportunities to health care providers to more effectively communicate, treat, and manage patient populations. However, in order to achieve effective and financially viable population management solutions, a number of elements are required. These include domain expertise in the health care spectrum, application of appropriate technologies, and analytics that address effectiveness and valuation issues (eg, cost, revenue streams) in generating proposed solutions in population management. This work provides a conceptual framework that illustrates the various elements essential to achieve success in population health management with an emphasis on behavioral health. These elements include domain-specific knowledge of medical ailments, application and management of appropriate technologies including digital platforms, and data and analytic approaches such as actuarial and financial informatics that are essential to achieving a sustainable valuation in managing the health of a population.