Interfaces between immiscible polymer melts can exhibit significant slip when subjected to large shear stresses. We describe and analyze a slip-link/tube model of the nonlinear steady-state rheology of an interface between entangled immiscible polymer melts. The model assumes that near equilibrium shear stress is transmitted across such an interface primarily by chains that form loops across the interface and entangle with chains of the other species. Such binary interfacial entanglements can be created by diffusion of chain ends to the interface and destroyed by either Brownian reptation or slipinduced convective constraint release. Interfacial stress is predicted to be a nonmonotonic function of interfacial slip velocity, leading to the possibility of a stick−slip transition between an entangled state with a very low slip velocity and an unentangled state with a much higher slip velocity.

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Cloud-based regulatory platforms have the potential to substantially transform how regulatory submissions are developed, transmitted, and reviewed across the full life cycle of drug development. The benefits of cloud-based submission and review include accelerating critical therapies to patients in need globally and efficiency gains for both drug developers and regulators. The key challenge is turning the theoretical promise of cloud-based regulatory platforms into reality to further the application of technology in the regulatory processes. In this publication we outline regulatory policy journeys needed to effect the changes in the external environment that would allow for use of a cloud-based technology, discuss the prerequisites to successfully navigate the policy journeys, and elaborate on future possibilities when adoption of cloud-based regulatory technologies is achieved.