Portable gamma cameras suitable for intraoperative imaging are in active development and testing. These cameras utilise a range of collimation, detection, and readout architectures, each of which can have significant and interacting impacts on the performance of the system as a whole. In this review, we provide an analysis of intraoperative gamma camera development over the past decade. The designs and performance of 17 imaging systems are compared in depth. We discuss where recent technological developments have had the greatest impact, identify emerging technological and scientific requirements, and predict future research directions. This is a comprehensive review of the current and emerging state-of-the-art as more devices enter clinical practice.

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