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This paper outlines a microstructure-based model relating gamma prime microstructure and grain size of Ni-base alloys to their creep behavior. The ability of the model to explain creep of multiple superalloys with a single equation and parameter set is demonstrated. The only parameters that are changed from alloy to alloy are related to the gamma prime characteristics and grain size. This model also allows prediction of creep performance as a function of heat treatment and explains some apparently contradictory data from the literature.