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The structure, ultrastructure, histochemistry, and immunohistochemistry of the suprapatella have been described in the rat. The suprapatella is a fibrocartilaginous sesamoid within the tendon of quadriceps femoris that articulates with the femoral condyles during flexion of the knee joint and reduces the amount of bending required at the tendon-bone junction. The cells of the suprapatella were much larger and more numerous than those in the associated tendon and were packed with vimentin-containing, intermediate filaments. The tendon cells contained far fewer filaments. The cells of both regions contained actin and tubulin. Histochemical and immunohistochemical studies showed that the suprapatellar cells were embedded in a matrix that is rich in chondroitin sulphate, but does not contain keratan or heparan sulphate. The fibrocartilage of the adjacent attachment zone of the quadriceps tendon also contained chondroitin sulphate, but in addition was rich in type II collagen. The structure of the suprapatella was similar to that of the fibrocartilaginous regions of tendons that pass around bony pulleys. However, there were differences in matrix composition that could reflect functional differences between the fibrocartilages.

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The findings support a policy of recommending SSRIs as first-choice antidepressants in primary care.