Nanopore-based sensing is attractive in the field of singlemolecule detection as it offers low-cost, label-free, and

Fluorescent nanoparticles with optically robust luminescence are imperative to applications in imaging and labeling. Here we demonstrate that hexagonal boron nitride (hBN) nanoparticles can be reliably produced using a scalable cryogenic exfoliation technique with sizes below 10 nm. The particles exhibit bright fluorescence generated by color centers that act as atomic-size quantum emitters. We analyze their optical properties, including emission wavelength, photon-statistics, and photodynamics, and show that they are suitable for far-field super-resolution fluorescence nanoscopy. Our results provide a foundation for exploration of hBN nanoparticles as candidates for bioimaging, labeling, as well as biomarkers that are suitable for quantum sensing.

By combining hydraulic pressure with ultrathin and 2D nanopores we demonstrate how pressure can support wetting of nanopores, as well as how pressure induced fluid flow can be used to identify and eliminate wetting artifacts.