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Fermi National Accelerator Laboratory has constructed a superconducting 1.3 GHz cavity test facility at Meson Detector Building (MDB) and an Advanced Accelerator Research Center (AARD) located at the New Muon Lab Building (NML). The control of these superfluid cryogenic systems is accomplished by using a Synoptic graphical user interface (GUI) to interact with the underlying Fermilab Accelerator Control System. The design, testing and operational experience of employing the Synoptic client-server system for graphical representation will be discussed. Details on the Synoptic deployment to the MDB and NML cryogenic sub-systems will also be discussed.

SUMMARYIntroduction: Dorzolamide 20mg/ml eye drops (dorzolamide hydrochloride (CAS: 120279-96-1)) is a topical carbonic anhydrase inhibitor indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. The aim: The aim of the present study was to assess the pharmacodynamic equivalence of two preparations of eye drops containing 20 mg dorzolamide (CAS: 120279-96-1). Method: The study was conducted as a monocentric, observer-blinded, randomized, single dose, single period study in thirty-six healthy volunteers. Each volunteer received in a random way after measurement of IOP intraocular pressure a single dose of 1 drop of the test product in the conjunctival sac of one eye and 1 drop of the reference drug in the conjunctival sac of the other eye. Measurement of intraocular pressure (IOP) of both eyes was performed on day 1 of each study period pre-dose and 2 h post dosing by means of Goldmann applanation tonometry. The two-sided 95% confi dence interval was calculated for the diff erence of the primary target parameter (absolute decrease in intraocular pressure 2 h post dose). Results:The statistical evaluation demonstrated a decrease in the IOP of 3.10 mmHg for the eye treated with the test formulation (dorzolamide 20mg/ml eye drops) and 3.23 mmHg for the eye treated with the reference formulation. The mean diff erence was -0.13 mmHg. The 95% confi dence interval was between -0.65 and 0.40 mmHg and thus entirely within the pre-defi ned equivalence range (±1.5 mmHg). Conclusion: Both formulations showed comparable results obtained at a time probably equal to the maximum eff ect concerning the primary target parameter lowering of intraocular pressure 2h post dose. The safety profi le of both preparations showed

SUMMARYObjective Surgical antimicrobial prophylaxis (SAP) is a method proved to be effective in reducing the risk of surgical site infections (SSI). Although there are numerous international and local Guidelines, SAP is often performed inappropriately. The monitoring that was carried out at the Surgery Clinic of the University Hospital "Tsaritsa Yoanna -ISUL" in August 2008 showed a high level of inappropriately performed SAP. In order to optimize SAP, a Local Guideline (LG) for SAP was developed. Methods LG for SAP was developed and implemented using the interdisciplinary approach, on the basis of internationally accepted standards of SAP, taking into account the specifics of the hospital. Monthly monitoring of the level of compliance of SAP with the LG for SAP was carried out. The use of antimicrobial agents (AMA) at the Clinic was reported using the DDD/100 patient day method. Results Three months after the LG implementation, the rate of appropriately performed SAP increased from 5% to 40% and at the end of 2009 even to 92%. The AMA usage in 2009 was reduced by nearly 26%: from total of 58.71 DDD/100 patient days in 2008 to 43.45 DDD/100 patient days and total AMA costs were reduced by more than 31%: from € 29.764 in 2008 to € 20.300 in 2009. Conclusions The interdisciplinary approach in the development and implementation of LG for SAP led to SAP optimization at the Surgery Clinic, significant reduction in AMA usage and considerable savings of financial resources.

Introduction: The rational use of drugs, especially antibiotics, has been recognized as a serious problem worldwide. Aim: The purpose of this study was to evaluate the practical skills of Bulgarian medical students in their fi nal year of education to prescribe antibiotics rationally as well as the impact of a training focused specifi cally on avoiding prescription errors. Materials/Methods: Medical students from the Medical University of Sofi a in their 10 th semester of education from two consecutive teaching cycles took part in this study. The students' participation was completely voluntary. The study was performed as academic study after having obtained a positive opinion from the Local Ethics Committee of the University Hospital "Tsaritsa Joanna-ISUL", Medical University of Sofi a. The study was planned to be conducted in two separate parts: a pilot study aimed at receiving basic information about the self-assessment confi dence of the medical students in prescribing drugs and especially antibiotics rationally and comparing this to their actual prescribing competence and a subsequent pivotal study after having performed a thorough analysis of the results of the pilot study with implementation of the respective corrective measures. The students' perception of their theoretical knowledge and practical skills to prescribe drugs and especially antibiotics rationally was assessed by means of a questionnaire containing 5 questions whereas their level of antibiotic prescribing competence was assessed by means of solving three simulated patient cases. The appropriateness of written therapeutic prescriptions was assessed independently by two clinical pharmacologists using a three-grade assessment scale: "good", "satisfactory" and "unsatisfactory". Results: The results of the pilot study showed that 50.35% of the prescriptions were rated as "good", 21.64% as "satisfactory" and 28.01% as "unsatisfactory". The results obtained from the subsequent pivotal study showed that 60.97% of the prescriptions were rated as "good" (representing a 21.1% increase), 16.23% as "satisfactory" (representing a 25% decrease) and 22.80% as "unsatisfactory" (representing an 18.6% decrease). This was accompanied by an increase in the students' self-assessment confi dence rated as "good"-from 19.15% to 34.21%, while "satisfactory" and "unsatisfactory" ratings decreased-from 65.96% to 55.26% and from 14.89% to 10.53%, respectively.