Due to the high light absorption and the possibility of localizing boiling to the interior of the receiver, nanoparticles are promising for solar-driven desalination. The paper presents an experimental study of the nanoparticle-based photothermal boiling of water with sea salt. The experiments were carried out using a laboratory-scale system with a transparent photothermal receiver of light and a closed condensate cycle. In this study, we tested three types of nanoparticles: multiwall carbon nanotubes with two main sizes of 49 nm and 72 nm, 110 nm iron oxide particles Fe3O4, and a commercial paste based on carbon nanotubes. The concentration of nanoparticles was varied up to 10% wt. We found that the nanoparticles enhance the steam generation by 23%, relative to a conventional desalinator with a black-body receiver. The best result was obtained for the 5% wt. concentration of carbon nanotubes.