Marqueurs cliniques des troubles immunitaires dans la pathogenèse de la coli entérite Introduction. La coli entérite est l'une des causes les plus courantes de diarrhée dans les pays développés et est généralement causée par des souches pathogènes d'Escherichia coli. Objectif: étudier le rôle de la réponse réactive des granulocytes neutrophiles polymorphonucléaires (GN) du sang périphérique dans les mécanismes de réponse inflammatoire systémique de l'entérocolite aiguë d'Escherichia (AEC) en fonction du polymorphisme des gènes de la protéine de choc thermique (HSP) de la famille 70-2 (HSP70-2, 1267A®G) et l'interleukine 10 (IL-10, C-592A). Méthodes. Le polymorphisme des gènes a été analysé par la méthode basée sur la PCR chez 95 patients avec AEC et 30 individus en bonne santé. Les marqueurs cliniques des troubles immunitaires ont été évalués à l'aide d'indices hématologiques, basés sur une analyse ABSTRACT Background. Escherichia coli enteritis is one of the most common causes of diarrhea in developed countries and is caused usually by pathogenic strains of Escherichia coli. Objectives. To investigate the role of reactive response of polymorphonuclear neutrophilic granulocytes (NG) of peripheral blood in the systemic inflammatory response mechanisms of acute Escherichia enterocolitis (AEC), depending on genes polymorphism of heat shock proteins (HSP) family 70-2 (HSP70-2, 1267A®G) and interleukin 10 (IL-10, C-592A). Material and methods. The genes polymorphism was analysed by PCR based method in 95 patients with AEC and 30 healthy individuals. Clinical markers of immune disorders were evaluated after hematological indices, based upon an extended general clinical blood analysis, using verified formulas. Results. The endogenous intoxication severity did not depend reliably on genotypes of IL-10 gene (rs1800872), however it was significantly 23.68%
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