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were diagnosed with left ventricular systolic dysfunction, compared to 26(31,7 %) in the intervention group. Also, and rate of admissions for heart disease was higher in the control group 28(34,1%) versus 17(20,7%) in the intervention group.Conclusions: Patients in the intervention group, in which the value of NTproBNP was used in choosing therapeutic management, have lower rate of heart failure or cardiovascular events than patients in the control group. This value NTproBNP in patients without heart failure can detect patients at risk of developing heart failure. And more, medical intervention guided by NTproBNP can prevent or delay heart failure in these patients.Objective: Slow breathing has favorable acute effects in chronic heart failure (CHF) patients. Aim of this study is to test the feasibility and efficacy of a new nonpharmacological CHF treatment method based on slow breathing training (SBT).Objective: To assess influence of antecedent hypertension on clinical course, cardiac hemodynamics and renal function in patients with acute decompensated heart failure (ADHF). Design and method:We performed a prospective observational study of patients admitted in cardiology ICU with ADHF. A total of 58 patients were enrolled including 40 men (69,0%) and 18 women (31,0%), mean age 64,2 ± 2,3 years. Patients were divided into 2 groups, gr.1 -n = 41 (70,7%) with antecedent hypertension and gr.2 -n = 17 (29,3%) without hypertension. The degree of kidney impairment was assessed by estimation of glomerular filtration rate (eGFR), plasma NT-pro-BNP (ELISA) was measured at the day of admission.Results: There was no significant difference between gr.1 and gr.2 for a frequency of diabetes mellitus 27 (65,9%) vs 10 (58,8%) and atrial fibrillation 15 (36,6%) vs 6 (35,3%), (all p > 0,05). In hypertensive patients renal damage (eGFR < 60 ml/min) was more frequent -24 (58,5%) vs 5 (29,4%), (p < 0,05). Also patients in gr.1 had higher ejection fraction -42,7 ± 2,2% vs 38,1 ± 2,1% (p < 0,05), had longer duration of stay in hospital 12,3 ± 2,1 vs 9,1 ± 1,9 days, (p < 0,05). NT-pro-BNP at the 1-st day was significantly higher in gr.1 comparing to gr.2 -1108 ± 317 vs 837 ± 284 pg/ml, (p < 0,02). Objective:The study aim was to evaluate whether circulating microparticles with apoptotic or none-apoptotic phenotypes are useful for risk assessment of three-year cumulative fatal and non-fatal cardiovascular events in chronic heart failure (CHF) patients.Design and method: It was studied prospectively the incidence of fatal and nonfatal cardiovascular events, as well as the frequency of occurrence of death from any cause in a cohort of 154 patients with CHF during 2 years of observation. Circulating levels of NT-pro brain natriuretic peptide (NT-pro-BNP), high-sensitivity C-reactive protein (hs-CRP), endothelial apoptotic microparticles (EMPs) were measured at baseline. Results:In the univariate logistic regression analysis, the main factors independently related with cumulative end-points were creatinine, fasting glucose, HbA1c, total chol...