Aim of the Study The aim of the study was to conduct an ultrasound (US) assessment of changes in fingernails in psoriatic patients with nail involvement. Material A total of 69 patients with psoriatic changes in nails participated in the study, including 38 patients with psoriasis (Ps) and 31 with psoriatic arthritis (PsA) and 30 people in the control group. A total of 988 nails were examined. Results The thickness of the nail plate, nail bed, and matrix as shown in an ultrasound examination increased with the mNAPSI index (r=0.328, p=0.021; r=0.219, p=0.036; and r=0.422, p=0.011, respectively). The thickness of nail plate, bed, and matrix in patients with onycholysis and hyperkeratosis-type changes (concomitant or present separately) was significantly greater than when only pitting-type changes occurred (p=0.007, p=0.035, and p=0.023, respectively). An examination of nails with only pitting-type changes showed an increase in the matrix thickness compared to the control group (p=0.018). The focal hyperechoic involvement of the dorsal plate (80%) was the change most often observed in an US examination in Ps patients, whereas loosening of the borders of the ventral plate was most often observed in PsA patients. The thickness of nail bed in PsA patients increased with the duration of arthritis (r=0.399, p=0.022) and was correlated with the number of swollen digits (r=0.278, p=0.041). Conclusions The findings of this study may indicate an association of an inflammation in the nail bed with PsA development. Apart from a direct assessment of the described morphological changes of nails, a US examination could prove useful in an assessment of intensity of a local inflammation as a prognostic factor for PsA development.

The aim of the study was an ultrasound assessment of distal interphalangeal (DIP) joint enthesopathy in patients with nail psoriasis. Altogether, 72 patients with nail psoriasis (41 with psoriasis and 31 with psoriatic arthritis) and 30 people in the control group participated in the study. In total, 1014 nails were examined. The thickness of DIP digital extensor tendons in the groups of patients with psoriasis (Ps) and psoriatic arthritis (PsA) was correlated with the nail bed thickness (r = 0.316, p = 0.027 vs. r = 0.402, p = 0.031, respectively) and with the thickness of the nail matrix in patients with psoriasis (r = 0.421, p = 0.012). The linear regression model showed the tendon thickness in Ps patients to be affected by the nail bed thickness, duration of psoriasis and the thickness of the nail matrix, whereas in PsA patients it was found to be significantly affected by duration of psoriasis and of arthritis, the nail bed thickness, CRP concentration and the swollen joint count. Our findings may indicate the role of the nail-tendon apparatus changes in the PsA development and they emphasise the justifiability of US examinations in patients with psoriasis direct assessment of morphological changes in nails as potential predictors of PsA development.

Ultrasound breast tomography (UBT) is a promising quantitative imaging method. It allows for precise analysis of ultrasound velocity distribution, which is related to tissue density and elasticity, enabling cancer detection. Only a few centers around the world have a prototype of the device for in vivo breast ultrasound tomography imaging. The quality of images reconstructed from measurements of ultrasound pulse transit times is adversely affected by the refraction of beam rays on the breast immersed in water. Refraction can be reduced using waveform tomography, ray-tracing, and ray-linking methods. However, this requires the acquisition of a pre-reconstructed pattern and is limited by extreme computational costs. In this study, the effect of refraction on transit time measurements of ultrasound passing through the female breast was analyzed under immersion conditions in water. It was found that the refraction causes the highest measurement errors in the area of the water/breast interface, and these can be reduced by adjusting the water temperature and changing the breast geometry. The results allow us to improve the quality of breast images reconstructed using an efficient transformation algorithm that assumes rectilinear ultrasound propagation paths between transmitters and receivers. In vivo breast studies were performed on the developed hybrid UBT scanner.

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Alternative radiological methods have been searched to improve early breast cancer detection. A prototype of a hybrid ultrasound tomography scanner was constructed as a novel non-invasive breast cancer screening method. The results of measurements with the new instrument were compared to conventional breast ultrasound, mammography, and magnetic resonance data from these same patients. The estimated hybrid ultrasound tomography scanner sensitivity was 74%, and specificity was 68%. Although these results do not match classical radiological methods yet, this preliminary report confirms the ability of the hybrid ultrasound tomography scanner to detect and visualize different types of breast lesions including breast cancer, providing a rationale for further research.