A detailed carbon- and oxygen-isotope stratigraphy has been generated from Upper Cretaceous coastal Chalk sections in southern England (East Kent; Culver Cliff, Isle of Wight; Eastbourne and Seaford Head, Sussex; Norfolk Coast) and the British Geological Survey (BGS) Trunch borehole, Norfolk. Data are also presented from a section through the Scaglia facies exposed near Gubbio, Italian Apennines. Wherever possible the sampling interval has been one metre or less. Both the Chalk and Scaglia carbon-isotopic curves show minor positive excursions in the mid-Cenomanian, mid- and high Turonian, basal Coniacian and highest Santonian–lowest Campanian; there is a negative excursion high in the Campanian in Chalk sections that span that interval. The well-documented Cenomanian–Turonian boundary ‘spike’ is also well displayed, as is a broad positive excursion centred on the upper Coniacian. A number of these positive excursions correlate with records of organic-carbon-rich deposition in the Atlantic Ocean and elsewhere. The remarkable similarity in the carbon-isotope curves from England and Italy enables cross-referencing of macrofossil and microfossil zones and pinpoints considerable discrepancy in the relative positions of the Turonian, Coniacian and Santonian stages.The oxygen-isotope values of the various Chalk sections, although showing different absolute values that are presumably diagenesis-dependent, show nonetheless a consistent trend. The East Kent section, which is very poorly lithified, indicates a warming up to the Cenomanian–Turonian boundary interval, then cooling thereafter. Regional organic-carbon burial, documented for this period, is credited with causing drawdown of CO2 and initiating climatic deterioration (inverse greenhouse effect). Data from other parts of the world are consistent with the hypothesis that the Cenomanian–Turonian temperature optimum was a global phenomenon and that this interval represents a major turning point in the climatic history of the earth.

SummaryThe neuromuscular junction (NMJ) plays a fundamental role in transferring information from lower motor neuron to skeletal muscle to generate movement. It is also an experimentally accessible model synapse routinely studied in animal models to explore fundamental aspects of synaptic form and function. Here, we combined morphological techniques, super-resolution imaging, and proteomic profiling to reveal the detailed cellular and molecular architecture of the human NMJ. Human NMJs were significantly smaller, less complex, and more fragmented than mouse NMJs. In contrast to mice, human NMJs were also remarkably stable across the entire adult lifespan, showing no signs of age-related degeneration or remodeling. Super-resolution imaging and proteomic profiling revealed distinctive distribution of active zone proteins and differential expression of core synaptic proteins and molecular pathways at the human NMJ. Taken together, these findings reveal human-specific cellular and molecular features of the NMJ that distinguish them from comparable synapses in other mammalian species.

A detailed isotopic profile is presented for a stratigraphically expanded Cenomanian–Turonian boundary section in Chalk facies exposed at Eastbourne, Sussex and compared with data from Pueblo, Colorado. In both sections macro- and micropalaeontological markers (first appearances and disappearances) are well-constrained, and their relative positions and relationship to the structure of the carbon-isotope curve are identical. This consistent relationship between two independent phenomena, one geochemical, the other biostratigraphical, is taken as evidence for the likely synchroneity of both the biostratigraphical markers and the carbon-isotope excursion in these two areas. This interpretation contrasts with suggestions made recently by other authors whose data have been taken to imply a lack of correlation between the carbon-isotope excursion in Europe and North America.

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We present a comprehensive revision and synthesis of the higher-level classification of the barnacles (Crustacea: Thecostraca) to the genus level and including both extant and fossils forms. We provide estimates of the number of species in each group. Our classification scheme has been updated based on insights from recent phylogenetic studies and attempts to adjust the higher-level classifications to represent evolutionary lineages better, while documenting the evolutionary diversity of the barnacles. Except where specifically noted, recognized taxa down to family are argued to be monophyletic from molecular analysis and/or morphological data. Our resulting classification divides the Thecostraca into the subclasses Facetotecta, Ascothoracida and Cirripedia. The whole class now contains 14 orders, 65 families and 367 genera. We estimate that barnacles consist of 2116 species. The taxonomy is accompanied by a discussion of major morphological events in barnacle evolution and justifications for the various rearrangements we propose.