Objectives: Occupational asthma and chronic obstructive pulmonary disease (COPD) are associated with the airway inflammatory process. The aim of this study was to compare the sputum and serum markers of inflammation in patients with occupational asthma and COPD. Methods: The study group included 20 patients with stable COPD, 24 patients with asthma, and 22 healthy subjects. Interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)-α, matrix metalloproteinase (MMP)-9 levels in serum and induced sputum as well as fibrinogen and CRP in serum were determined in all the subjects. Results: Higher concentrations of IL-1β, IL-6, TNF-α, and MMP-9 in induced sputum and an increased concentration of acute-phase proteins in serum were observed in COPD patients compared with healthy subjects. Higher concentrations of IL-1β and MMP-9 in induced sputum and a higher concentration of C-reactive protein (CRP) were detected in COPD patients than in asthmatic subjects. Never smokers with COPD had significantly higher levels of IL-1β and MMP-9 in induced sputum than never smoker controls. There was no significant difference between the serum and sputum levels of cytokines and MMP-9 of never smokers and smokers with COPD. Conclusions: Higher concentrations of IL-1β and MMP-9 in induced sputum and a higher concentration of CRP in serum allow distinguishing between biomarker profiles of COPD patients and asthmatic patients. Occupational exposure induces a systemic proinflammatory state with increased levels of acute-phase proteins in stable COPD patients. MMP-9 and IL-1β concentrations are increased in induced sputum of never smokers with COPD, which is associated with occupational exposure.

StreszczenieDym tytoniowy zawiera tysiące czynników chemicznych szkodliwych dla zdrowia człowieka. Mają one działanie drażniące, toksyczne i rakotwórcze. Bierne palenie tytoniu w miejscach publicznych i narażenie na środowiskowy dym tytoniowy także w miejscu pracy stanowią ogromny problem medyczny. Wynika z niego potrzeba uświadamiania pracowników w zakresie szkodliwości nałogu palenia tytoniu oraz stworzenia aktów prawnych mających na celu wyeliminowanie narażenia na dym tytoniowy. W niniejszej pracy przedstawiono wyniki przeglądu piśmiennictwa na temat biernej ekspozycji na dym tytoniowy i jej wpływu na zdrowie człowieka oraz dokonano przeglądu obowiązujących w Polsce aktów prawnych dotyczących palenia papierosów w miejscu pracy. Dotychczas opublikowane dane wskazują, że ekspozycja na dym tytoniowy w okresie życia płodowego zwiększa ryzyko m.in. porodu przedwczesnego i małej masy urodzeniowej noworodka, nagłej śmierci niemowląt oraz w przyszłości -upośledzenia funkcji płuc, astmy i ostrych schorzeń dróg oddechowych. Narażenie na dym tytoniowy, także wyłącznie w wieku dorosłym, jest natomiast niezależnym czynnikiem ryzyka rozwoju schorzeń układu krążenia i układu oddechowego oraz nowotworów złośliwych. Podniesienie świadomości społecznej na temat szkodliwości ekspozycji na dym tytoniowy powinno być priorytetem w ochronie zdrowia pracujących. Lekarz sprawujący opiekę profilaktyczną nad pracownikami jest przedstawicielem służby zdrowia, który ma najczęstszy kontakt z aktywnymi zawodowo dorosłymi palaczami tytoniu. Wynika z tego niezwykle istotna rola służby medycyny pracy w zwiększaniu świadomości pracowników i pracodawców w zakresie profilaktyki negatywnych skutków zdrowotnych nałogu palenia tytoniu. Med. Pr. 2015;66(6):827-836 Słowa kluczowe: palenie tytoniu w miejscu pracy, zakaz palenia w miejscu pracy, bierne palenie, bierna ekspozycja na dym tytoniowy, środowiskowy dym tytoniowy, profilaktyka AbstractTobacco smoke contains thousands of xenobiotics harmful to human health. Their irritant, toxic and carcinogenic potential has been well documented. Passive smoking or exposure to second-hand smoke (SHS) in public places, including workplace, poses major medical problems. Owing to this fact there is a strong need to raise workers' awareness of smoking-related hazards through educational programs and to develop and implement legislation aimed at eliminating SHS exposure. This paper presents a review of reports on passive exposure to tobacco smoke and its impact on human health and also a review of binding legal regulations regarding smoking at workplace in Poland. It has been proved that exposure to tobacco smoke during pregnancy may lead to, e.g., preterm delivery and low birth weight, sudden infant death syndrome, lung function impairment, asthma and acute respiratory illnesses in the future. Exposure to tobacco smoke, only in the adult age, is also considered as an independent risk factor of cardiovascular diseases, acute and chronic respiratory diseases and cancer. Raising public awareness of tobacco smoke ha...

Eosinophilic bronchitis (EB) is a condition which can be associated with occupational exposure to low, as well as to high molecular weight allergens. The prevalence of occupational eosinophilic bronchitis is unknown and the data concerning its work-related etiology are available only from the case reports. However, there is a need to establish the principles, especially in the context of medical certification among workers occupationally exposed to allergens. This paper reviews current knowledge on the etiology, clinical features, and diagnostic procedures in the eosinophilic bronchitis. The importance of EB, especially in view of the problems emerging in the prophylactic care taken by occupational health services and the principles of medical certification when occupational etiology is suspected are also presented.

Severe occupational systemic reactions to persulphates have rarely been described and if so mainly after skin contact with bleaching products. We report the first case of a hairdresser with an allergy to persulphates obtained during professional work, who developed anaphylaxis caused by persulphates present in dental cement during dental treatment. This case documents that sensitization to occupational allergens can induce severe systemic reactions outside the workplace. Additionally, it also recommends the need for greater awareness of medical professionals, including dentists, of the possibility of anaphylaxis in patients with occupational allergy.

Objectives: Chronic obstructive pulmonary disease (COPD) may be work-related. It has been estimated that 15% of the population burden of COPD is attributable to occupational exposure. However, in Poland COPD is rarely recognized as an occupational disease. The aim of the study has been to analyze the causes of the low prevalence of work-related COPD in the context of the existing criteria as well as to analyze which part of the assessment -clinical or hygienic one -is responsible for such a low rate of occupational COPD recognitions. Material and Methods: The study group included 150 patients hospitalized with a suspicion of occupational COPD. Each patient underwent a clinical examination, spirometry and reversibility test using bronchodilator. Moreover, hygienic evaluation of work conditions was performed in all the considered cases. Results: In the case of the patients who fulfilled the criteria for COPD diagnosis in accordance with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) occupational origins of the disease, the disease was not recognized because 24.1% of the individuals did not meet spirometric criteria included in a definition of COPD in the Polish list of occupational diseases, while 27.8% of the individuals did not fulfill the criterion of a documented exposure to dusts and irritant gases. None of these criteria was fulfilled by 42.6% of the patients. Conclusions: In our country, both clinical and hygienic criteria result in limitations in recognition of occupational COPD. There is the need to establish new guidelines for the recognition of COPD as a compensable disease in Poland. Int J Occup Med Environ Health 2018;31(2):139 -150