Medicinal plants are currently employed for curative purposes in developing and developed countries. One example is garlic (Snow mountain garlic, also called "Himalayan garlic"), used for its multiple therapeutic properties since ancient times. The local Himalayan population generally consumes it as a remedy for rheumatoid arthritis. This study aimed to evaluate the antinociceptive and anti-inflammatory effect of a "Snow mountain garlic" extract in a formalin test. Nociception was measured (number of paw flinches/shakes during one h for 5 min periods), under the administration of 50 µL with formalin 5%, saline solution 0.9%, Snow mountain essential oil 500 µg/kg, diclofenac 250 µg/kg, naproxen 400 µg/kg, and tramadol 500 µg/kg in independent groups. Snow mountain garlic extract has an antinociceptive effect on Phase 2 of the formalin test, which is associated with the inflammatory component of pain, and its behaviour is comparable to that of traditional NSAIDs used in the clinic. RezumatPlantele medicinale sunt folosite în prezent în scopuri curative în multe țări. Un exemplu este usturoiul (usturoiul de munte, numit și "usturoiul de Himalaya"), folosit pentru multiplele sale proprietăți terapeutice încă din cele mai vechi timpuri. Populația locală din Himalaya îl consumă în general ca remediu pentru artrita reumatoidă. Acest studiu și-a propus să evalueze efectul antinociceptiv și antiinflamator al acestuia utilizând modelul experimental al formolului. S-a măsurat nocicepția (număr de tresăriri/agitări de labe pe parcursul unei ore, timp de 5 minute), după administrarea a 50 µL formol 5%, soluție salină 0,9%, ulei esențial Snow Mountain 500 µg/kg, diclofenac 250 µg/kg, naproxen 400 ug/kg şi tramadol 500 ug/kg în grupuri independente. Extractul are un efect antinociceptiv în faza 2 a experimentului, care este asociat cu componenta inflamatorie a durerii, acest efect fiind comparabil cu cel al AINS clasice.
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