Therapeutic radiopharmaceuticals have been researched extensively in the last decade as a result of the growing research interest in personalized medicine to improve diagnostic accuracy and intensify intensive therapy while limiting side effects. Radiometal-based drugs are of substantial interest because of their greater versatility for clinical translation compared to non-metal radionuclides. This paper comprehensively discusses various components commonly used as chemical scaffolds to build radiopharmaceutical agents, i.e., radionuclides, pharmacokinetic-modifying linkers, and chelators, whose characteristics are explained and can be used as a guide for the researcher.

A molecularly imprinted polymer (MIP) is a synthetic polymer that has characteristics such as natural receptors which are able to interact and bind to a specific molecule that is used as a template in the MIP polymerization process. MIPs have been widely developed because of the need for more selective, effective, and efficient methods for sample preparation, identification, isolation, and separation. The MIP compositions consist of a template, monomer, crosslinker, initiator, and porogenic solvent. Generally, MIPs are only synthesized using one type of monomer (mono-functional monomer); however, along with the development of MIPs, MIPs began to be synthesized using two types of monomers to improve the performance of MIPs. MIPs used for identification, separation, and molecular analysis have the most applications in solid-phase extraction (SPE) and as biochemical sensors. Until now, no review article has discussed the various studies carried out in recent years in relation to the synthesis of dual-functional monomer MIPs. This review is necessary, as an improvement in the performance of MIPs still needs to be explored, and a dual-functional monomer strategy is one way of overcoming the current performance limitations. In this review article, we discuss the techniques commonly used in the synthesis of dual-functional monomer MIPs, and the use of dual-functional monomer MIPs as sorbents in the MI-SPE method and as detection elements in biochemical sensors. The application of dual-functional monomer MIPs showed better selectivity and adsorption capacity in these areas when compared to mono-functional monomer MIPs. However, the combination of functional monomers must be selected properly, in order to achieve an effective synergistic effect and produce the ideal MIP characteristics. Therefore, studies regarding the synergistic effect of the MIP combination still need to be carried out to obtain MIPs with superior characteristics.

Kanker melanoma merupakan sebuah keganasan yang terjadi pada sel melanosit. Karakteristik dari kanker ini yaitu tonjolan dan warna yang tidak beraturan pada kulit. Pengobatan yang digunakan saat ini salah satunya adalah agen kemoterapi vemurafenib. Seperti yang telah diketahui, agen kemoterapi dapat menyebabkan berbagai efek samping pada tubuh. Oleh karena itu, dilakukan pencarian senyawa lain yang berpotensi dan menghasilkan efek samping lebih sedikit. Penelitian ini dilakukan dengan pendekatan in silico yaitu penambatan molekuler. Dilakukan juga prediksi terhadap profil farmakokinetik menggunakan aturan Lipinski dan PreADMET. Senyawa dari daun tanaman sirsak (Annona muricata L.) diketahui memiliki potensi untuk menghambat aktivitas pembelahan sel melalui interaksi dengan reseptor BRAF V600E. Reticuline diketahui memiliki nilai energi Gibbs sebesar -8,78; nilai konstanta inhibisi sebesar 395.39 nM; dan berikatan pada asam amino