Abstract. The prevalence of obesity is increasing in dogs as well as in humans. C-reactive protein (CRP) is an important tool for the detection of inflammation and/or early tissue damage and is linked to obesity in humans. The objective of the present study was to determine if serum CRP levels are altered in obese dogs. Fifteen lean (control group) and 16 overweight (obese group) dogs were examined. Blood samples were collected under fasted conditions for serum determination of CRP, glucose, insulin, cholesterol, triglyceride, and fructosamine. Results indicated that obese dogs were insulin resistant because serum insulin and insulin/ glucose ratios were higher than in lean dogs (P # 0.05). Serum CRP concentrations were lower in obese dogs than in controls (P # 0.001). C-reactive protein was negatively correlated with insulin/glucose ratio (R 5 20.42) and cholesterol (R 5 20.39; P # 0.05). Furthermore, levels of cholesterol, triglycerides, and fructosamine were increased in the obese group compared with the control group. Based on these results, it can be postulated that CRP production is inhibited by obesity and insulin resistance in dogs.
Resumo -O objetivo deste trabalho foi verificar a influência da idade, sexo, manejo e estado gestacional sobre a atividade sérica das enzimas: aspartato aminotransferase (AST), creatina quinase (CK) e gama-glutamiltransferase (GGT) em cavalos da raça Crioula. Foram utilizados 142 eqüinos, divididos em seis grupos: potros até um ano de idade; cavalos adultos em regime de atividade livre; cavalos adultos em treinamento; machos adultos; fêmeas não gestantes; fêmeas gestantes. O valor da CK foi mais elevado em animais adultos do que em potros, o mesmo tendo ocorrido em animais em atividade livre, comparados a animais em treinamento. Fêmeas não gestantes apresentaram valores das enzimas CK e GGT maiores que os machos; o valor da CK em fêmeas gestantes foi mais elevado do que em fêmeas não gestantes. A idade, o sexo, o manejo e o estado gestacional influenciam a atividade sérica da CK, e o sexo influencia a atividade sérica da GGT.Termos para indexação: bioquímica sérica, enzimas musculares, doenças hepáticas, miopatia. AST, CK and GGT enzymes serum activities in Crioulo horsesAbstract -The objective of this work was to evaluate the influence of age, sex, management and pregnancy status on aspartate aminotransferase (AST), creatine kinase (CK) and gamma-glutamyltransferase (GGT) enzymes serum activities of Crioulo horses. One hundred and forty-two horses, divided into six group were analyzed: yearlings; free activity of adult horses; training adult horses; male adult horses; nonpregnant and pregnant females. The CK enzyme activity value was higher in adult horses than in yearlings, and the same result was found when comparing free activity and training horses. Nonpregnant females had higher values for CK and GGT comparing to male horses, and CK values were higher in pregnant comparing to nonpregnant females. Age, sex, management and pregnancy status influence on CK serum activity, and sex influences on GGT serum activity.Index terms: serum biochemistry, muscular enzyme, hepatic disease, myopathy. IntroduçãoOs sinais clínicos presentes em distintas alterações musculares são semelhantes e bastante inespecíficos; por isso, quando isolados, eles têm limitado valor diagnóstico, o que requer, freqüentemente, o uso de exames laboratoriais complementares. Entre as enzimas, cujas concentrações séricas devem ser determinadas quando de disfunções musculares, estão aspartato aminotransferase (AST) e a creatina quinase (CK) (Da Cás et al., 2000). Além disso, a patogenia de doenças hepáticas nos animais domésticos é muito complexa, por isso, o diagnóstico dessas enfermidades também envolve testes bioquímicos, entre os quais o uso da enzima gama-glutamiltransferase (GGT) como marcador sérico primário, para doenças do sistema hepatobiliar associadas com colestase (Tennant, 1997).A aspartato aminotransferase (AST) é uma enzima citoplasmática e mitocondrial, presente em vários tecidos como fígado, músculos esquelético e cardíaco (Tennant, 1997;Frape, 1998). Tennant (1997) salienta que em todas as espécies domésticas a atividade da AST ...
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