Since March 2020, many employees around the world have been forced to work from home due to the COVID‐19 global pandemic. Astronauts aboard the International Space Station (ISS) have experience in working in isolation and confinement. This paper focuses on a comparison of astronauts on the ISS and Earth‐bound architects and interior designers restricted to working from home (i.e. their sofas) due to the pandemic. Isolation at work emerges as a complex phenomenon characterized by the measured and perceived distances between physical, social, and temporal spaces. By examining the scale‐making activities of NASA and HKS, analogs provide a possible means for studying and predicting the complex dimensions of isolation. The work ecosystem is a useful tool in conceptualizing and operationalizing the employee experience to design the future of work and workspaces.