No abstract

The average dietary sodium intake of adults living in the United States is estimated to be 3600 mg per day. 1 This is higher than the 2019 Institute of Medicine guidelines that recommend an upper limit of 2300 mg of sodium per day in adults and substantially greater than American Heart Association guidelines, which target an upper limit of 1500 mg per day. 2,3 Higher dietary sodium intake induces a range of physiological changes including intravascular volume expansion, increased glomerular filtration rate, and suppression of renin-angiotensin-aldosterone-system (RAAS) activity. 4 Although the mean dietary sodium intake in the United States may be high, studies have consistently shown that there is large intra-individual variability in day-today sodium intake and excretion. 1,5,6 This variability implies that downstream physiological processes that are influenced by sodium intake may also be variable. 24-hour urinary free cortisol (24hUFC) is a screening test commonly used to assess for endogenous hypercortisolism. 7 Previous studies