The results of a study of the concentration of vitamin D in blood serum of 3455 residents of Ufa are presented. Physiological values of 25(OH)D were observed in 34.9 % (274) of men and 31.7 % (847) of women, which is 32.4 % (1121) of all examined. Vitamin D deficiency was detected in 67.1 % of the examined. The level of 25(OH)D in the blood serum of residents is on average 75 nmol/L, which is the upper limit of vitamin D deficiency. Vitamin D deficiency is extremely common among residents of this region of the Russian Federation (67.1 %).

The results of a study of the concentration of vitamin D and parathyroid hormone in 353 residents of the Republic of Bashkortostan in blood serum. The frequency of hypovitaminosis and a deficiency of 25 (OH) D in the older age groups of the population of the Republic of Bashkortostan is excessively high, the level reaches 77.1 %. The average value of parathyroid hormone was 55.1 ± 26.33 pg/ ml, vitamin D –22.57 ± 12.24 ng / ml. A negative correlation between 25 (OH) D and the level of PTH is characteristic (r = –0.144, p <0.001). Normal level of parthyrin was detected in 89.8 %, an excess in 8.8 % of the studied, which indicates the active work of the gland in conditions of cholecalciferol deficiency.

Vitamin D affects estrogen level by stimulating the synthesis of testosterone, estrogen and progesterone. Insufficiency of vitamin D leads to a decrease in the values of these steroid hormones. The average value of 25 (OH) D was 26.95 ± 16.6 ng/ml, which indicates insufficiency. The median estradiol was 47.85 pg/ml, which is below the reference values during the follicular phase. Vitamin D deficiency in this sample may be one of the reasons. Prophylactic vitamin D and calcium supplementation will contribute to the improvement of this situation.

An analysis of occupational risks to the health of workers, the fundamental components of which are injuries and occupational morbidity, is extremely relevant, primarily for those industries where working conditions remain difficult and harmful and there are restrictions on hiring for health reasons, including at mining enterprises mineral. The purpose of the work is to study the consequences of exposure to harmful and (or) dangerous working conditions for employees of the main types of economic activity and mining of the Republic of Bashkortostan for the period 2011–2020. and comparing them with similar data for the Russian Federation. Sources of information — statistical reports, reports and materials published on the official websites rosstat.gov.ru, rospotrebnadzor.ru, 02.rospotrebnadzor.ru, bashstat.gks.ru, mintrud.gov.ru, mintrud.bashkortostan.ru. The average long-term level of occupational morbidity in Russia for the study period was 1.45 per 10 thousand workers, in the Republic of Bashkortostan — 0.910/000. A steady decrease in intensive indicators of occupational morbidity in dynamics by 2.5 times in Russia and almost 3 times in the republic was noted. The average annual rates of occupational morbidity in the production of minerals in the country ranged from 21.2 in 2019 to 32.75 in 2013 per 10 thousand employees (average 29.04 0/000), in the republic — 6.0 per 10 thousand employees, which is 7.3 times higher than the national average. The average number of victims with disability for all types of economic activity in Russia was 1.2 times higher than the national indicator, the average injury severity indicator in the region exceeded the same value in the country by 11.4 %. An excess of the average long-term indicator of the frequency and severity of injuries at the country's mining enterprises in comparison with the indicators of general injuries was noted. The data convincingly testify to the existing problems in the production of minerals, causing increased rates of occupational morbidity and occupational injuries with severe outcomes.