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As palm oil has been qualified as atherogen, we have studied the impact of its consumption on changes of lipid and lipoprotein profiles of young Ivorian healthy subjects living in rural areas. It is a descriptive cross-sectional analytical study of about 120 Ivorian subjects aged 18 to 30 years, including 65 regular consumers of palm oil and 55 subjects consuming that oil periodically as control subjects. Serum concentrations of triglycerides, total cholesterol, HDL, LDL cholesterols and lipoprotein (a) were measured by enzyme conventional methods. The TC serum varied not significantly in both subjects' groups as the triglycerides and HDL-C did. In addition, 58.46% of palm oil consumers had hypoLDLemia. The serum concentration of lipoprotein (a) was not significantly elevated (p> 0.05) with consumers compared to controls: 33.85% versus 29.09%, p = 0.55. The percentage of subjects with normal serum concentrations is higher in all the studied parameters, with both that is the consumers and the controls, except LDL cholesterol, of which the percentage of subjects with a lower value is the highest (58.46% for consumers and 52.73% for controls). This study has shown that the consumption of palm oil did not alter the lipid and lipoprotein profile of the consumer, on the contrary, this consumption revealed a decrease in cholesterol levels with these subjects.

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In the eukaryotic cell, phospholipids can be biosynthesized by two pathways, one from choline and the other one from ethanolamine. The functional effectiveness of each pathway depends on the type of the cell. Thiazolium designed-drugs have shown, under in vivo conditions, antiplasmodial and antimalarial activities with inhibition of the phospholipids biosynthesis. This study aimed to discover the pathways involved in the biosynthesis of phospholipids in Plasmodium and deduce the biochemical steps inhibited by T4, a bis-thiazolium bromide drug. We compared the uptake of radiolabeled precursors and their selective incorporation in the phospholipids of cultured Plasmodium-infected and -uninfected erythrocytes which revealed that phosphatidylcholine of Plasmodium is synthesized both from choline and ethanolamine (4.7 vs 1.9 nmol/10 10 cells.h -1). T4 has no effect on the biosynthesis of phosphatidylethanolamine but T4 inhibited, in a selective way, the in vitro uptake of choline. However no enzymes in the biosynthesis of phospholipids seem to be inhibited by T4 but rather an inhibition of choline entry into the parasite.