The data suggest that autonomic cardiovascular regulation in FMS is impaired in terms of reduced sympathetic and parasympathetic influences, as well as baroreflex malfunctioning. Furthermore, autonomic cardiovascular adjustment to acute stress is blunted. The inverse association between BRS and pain severity reflects the well-documented pain inhibition through the baroreceptor system. On account of this and the reduced baroreflex function in FMS, one may assume deficient ascending pain inhibition arising from the cardiovascular system, which may contribute to hyperalgesia that is characteristic of the disorder.

No abstract