This paper reports the magnetohydrodynamic dissipative fluid flow towards a stretching/shrinking surface with Joule heating, non-uniform heat source/sink, Brownian motion, thermophoresis and cross diffusion effects. The transformed governing equations are explored numerically by shooting technique. The consequences for different pertinent parameters on the flow, thermal and concentration distributions are explained with the assistance of tables and graphs. The wall friction, local Sherwood and reduced Nusselt number is also computed and analyzed. The solutions are exhibited for Casson fluid case. It is found that an increase in the Prandtl number enhances the heat and mass transfer rate.