Currently, the main form of malignancy among women is breast cancer. With the advent of radiotherapy, conservative breast surgery (lumpectomy) has become a possible technique. However, radical mastectomy still maintains its indications in the face of a more advanced pathology or in patients with deleterious BRCA 1 / BRCA 2 mutations. Unfortunately, complications of the surgical wound exist. Faced with this problem, PICO ™ Softpor - Negative pressure wound therapy system, is a unique device that has been used in the negative pressure wound therapy system to improve wound healing, this includes improved perfusion, removal of excess fluid and edema leading to less tension in the surgical wound. The study aimed to report the experience of using the Wound Negative Pressure Therapy System through PICO ™ Softport in the surgical treatment of breast cancer through a case report. Patient M. R. V., female, 57 years old, G2P2A0, asymptomatic with a diagnosis of T4BN0M0 in the right breast and T1N0M0 in the left breast was submitted to bilateral modified radical mastectomy. We used bilateral dressings with the Wound Negative Pressure Therapy System in the form of PICO ™ Softport, which made it possible to reduce the incision healing complications. After surgical recovery, the patient underwent adjuvant radiotherapy, presenting himself until the moment of this stable report using anastrozole, being completely satisfied with the dermal healing result that the device provided.