Background: Pancreatitis caused after transurethral resection of the prostate (TURP) is an uncommon complication, with few reports found in the literature. Here we present the case of a middle-aged patient without comorbidities with this pathology. Clinical case: A 66-year-old male patient with no prior medical history underwent TURP surgery due to benign prostatic hyperplasia. The evolution was unfavourable, leading to post TURP syndrome. On the fifth day after surgery, the patient was admitted for emergency dialysis. During his emergency stay, the patient was unstable; he was diagnosed with pancreatitis, moving to an intensive care unit for management The patient progressed favourably from renal failure and pancreatitis, and on the 5th day the patient was discharged, tolerating oral feeding and stabilized renal failure. Conclusions: Pancreatitis caused by TURP is very rare. This complication has been reported in the literature infrequently and should be suspected when there is pain in the epigastrium. If this complication is suspected, imaging tests and pancreatic enzyme levels should be immediately requested, as it can have an unfavourable evolution until death.