Problem-based learning is used to develop high order thinking skills, in problem-oriented situations, including how to learn. Problem-based learning is a learning model dependent on the rule that issues can be utilized as a beginning stage to get or coordinate new information. This study aimed at determining the effect of problem based learning models with student worksheets on students' high order thinking skills on the digestive system concept. In this study problem solving steps were developed in a student worksheets. This student worksheets contains questions that can develop students' thinking skills, from low-order thinking to high-order thinking. High order thinking skills measured in this study is limited to Bloom's taxonomy of cognitive revisions analysing (C4), evaluating (C5) and creating (C6) The research method used was quasi experiment with the design of the non-equivalent controlled group design. The subjects in this study were students of SMAN 8 Tangerang Selatan Academic Year 2015/2016. The sampling technique in this study was by simple random sampling. The sample in this study consisted of two classes: XI IPA 1 as the experimental group and XI IPA 5 as the controlled group, each had 32 students. The instrument was in the form of subjective tests using 13 items, each of 5 questions to analyse (C4), 5 questions to evaluate (C5) and 3 questions to create (C6). The data of the test results were analysed by using the t-test, at a significance level of 0.05. Based on the result, it has found that problem based learning models with student worksheets had a significant effect on students' high order thinking skills on the digestive system concept. This study aims to identify the impact of problembased learning (PBL) to students' higher-order thinking skill. The notion of higher-order thinking is designed based on Bloom's taxonomy, and implemented into students' worksheet particularly on the topic of digestive system concept. 64 students from two science classes at a secondary high school in South Tangerang participated in this experimental study. Findings of the study revealed that problem-based learning models with student worksheets had a significant effect on students' high order thinking skills on the digestive system concept.