Position emission tomography using 6-FDOPA as a marker of presynaptic dopaminergic activity was used to investigate the role of the dopamine system in stuttering. Three patients with moderate to severe developmental stuttering were compared with six normal controls. Stuttering subjects showed significantly higher 6-FDOPA uptake than normal controls in medial prefrontal cortex, deep orbital cortex, insular cortex, extended amygdala, auditory cortex and caudate tail. Elevated 6-FDOPA uptake in ventral limbic cortical and subcortical regions is compatible with the hypothesis that stuttering is associated with an overactive presynaptic dopamine system in brain regions that modulate verbalization.

Introduction: American Indian (AI) youth experience poor sexual health outcomes. Research indicates the Protection Motivation Theory (PMT) is a robust model for understanding how sexual risk and protective behaviors are associated with condom use intention (CUI). Studies indicate the constructs of the PMT which influence CUI vary by sex and sexual experience. This analysis explores associations between PMT constructs and CUI by sex and sexual experience among AI youth who participated in the Respecting the Circle of Life (RCL) trial, a sexual and reproductive health intervention.Methods: We analyzed baseline data from the sample of 267 AIs, ages 13–19, who participated in the evaluation. We examined CUI and PMT construct scores by sex and sexual experience utilizing generalized estimated equations and multiple regression models to test which PMT constructs were associated with CUI across sex and sexual experience.Results: Twenty-two percentage of participants were sexually experienced; 56.8% reported CUI at baseline. We found several differences in scores in PMT constructs by sex and sexual experience including self-efficacy, response efficacy, vulnerability, severity, and extrinsic rewards. We also found constructs varied that were associated with CUI varied across sex and sexual experience. No PMT constructs were associated with CUI among sexually experienced youth.Conclusion: Results provide support for developing, selecting and delivering sexual health programs by sex and sexual experience in American Indian communities. Girls programs should focus on internal satisfaction and self-worth while boys should focus on negative impacts of not using condoms. Programs for youth who are not sexually active should focus on negative impacts of not using condoms. Programs for sexually inactive youth should work to change peer norms around condom use and improve knowledge about the efficacy of condom use.

confirmation; syphilis using TPPA/VDRL confirmation for active syphilis. Results A total of 316 female adolescents and 384 males participated. A history of sexual activity was reported by 76.0% of females and 78.3% of males; forced sexual intercourse by 29.0%(86/297) of females and 15.1%(55/364) of males; transactional sex (being offered money, food, housing, transport in exchange for sex) by 14.6%(43/295) of females, 12.3%(45/ 365) of males. Of sexually experienced participants, 4.7%(25/ 535) had a confirmed HIV (1 female, 3 males) or active syphilis (3 females, 19 males) test. Correlates of either HIV/syphilis infection include: male gender (AOR=4.4, 95%CI: 1.5-13.1) and having been offered transactional sex (AOR=3.3, 95%CI: 1.3-8.0). Among males only, 4/26 (15.4%) of those who reported same-sex sexual intercourse (MSM) tested positive for syphilis. Correlates of HIV/syphilis among all male participants included transactional sex (AOR=2.7, 95%CI: 1.0-7.9), having been forced to have sex (OR=2.6, 95%CI: 1.0-6.9) and MSM (OR=2.7, 95%CI: 0.9-8.9). Conclusion There is very high syphilis and HIV prevalence among high-school-going indigenous adolescents of CNB, particularly among males. Transactional sex and forced sex are driving factors. Targeted interventions should include prevention education, testing and treatment, especially for boys reporting homosexual sex. Disclosure No significant relationships.

confirmation; syphilis using TPPA/VDRL confirmation for active syphilis. Results A total of 316 female adolescents and 384 males participated. A history of sexual activity was reported by 76.0% of females and 78.3% of males; forced sexual intercourse by 29.0%(86/297) of females and 15.1%(55/364) of males; transactional sex (being offered money, food, housing, transport in exchange for sex) by 14.6%(43/295) of females, 12.3%(45/ 365) of males. Of sexually experienced participants, 4.7%(25/ 535) had a confirmed HIV (1 female, 3 males) or active syphilis (3 females, 19 males) test. Correlates of either HIV/syphilis infection include: male gender (AOR=4.4, 95%CI: 1.5-13.1) and having been offered transactional sex (AOR=3.3, 95%CI: 1.3-8.0). Among males only, 4/26 (15.4%) of those who reported same-sex sexual intercourse (MSM) tested positive for syphilis. Correlates of HIV/syphilis among all male participants included transactional sex (AOR=2.7, 95%CI: 1.0-7.9), having been forced to have sex (OR=2.6, 95%CI: 1.0-6.9) and MSM (OR=2.7, 95%CI: 0.9-8.9). Conclusion There is very high syphilis and HIV prevalence among high-school-going indigenous adolescents of CNB, particularly among males. Transactional sex and forced sex are driving factors. Targeted interventions should include prevention education, testing and treatment, especially for boys reporting homosexual sex. Disclosure No significant relationships.

15), p=0.014) was associated with reduced SSE. Among sexually active participants (n=115), increased SSE was associated with increased condom use among young women (b: 1. 40[0.19, 2.61], p=0.024) and men (b: 2.14 [0.14, 4.14], p=0.036). No differences emerged by Indigenous identity across analyses. Conclusion Food insecurity and IPV emerged as syndemic factors associated with lower SSE-a protective factor associated with condom use among Northern and Indigenous adolescents in the NWT. Poverty and violence compromise Indigenous and Northern youth's sexual agency and in turn contribute to STI vulnerabilities, requiring urgent attention. Disclosure No significant relationships.