Diabetes mellitus is a group of metabolic diseases in which high blood glucose levels occur over a prolonged period. Hyperglycemia is caused by defective insulin secretion or impaired biological function, whereas long-term hyperglycemia can lead to chronic damage dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves (Home & Home, 2005). According to the World Health Organization, there are more than 100 complications of diabetes. Clinical data have shown that there will be at least one complication in 30%-40% of patients within approximately 10 years of the onset of diabetes, and once the complications occur, drug treatment is difficult to reverse (Sen & Chakraborty, 2015). Therefore, it is emphasized to prevent diabetes complication as early as possible. Diabetic nephropathy (DN) is one of the most important complications in diabetic patients. It is now the second leading cause of end-stage renal disease (ESRD),