Aim: Studies on the anticancer effects of synbiotic fermented soymilk are rare. The aim of the present study was to evaluate the effect of synbiotic fermented soymilk supplemented with xylooligosaccharides and inoculated with Weissella cibaria FB069 (FSMXW) in the proliferation of colon cancer cell and compare it with the effect of soymilk inoculated with Lactobacillus rhamnosus GG (LGG). Methods and Results: Both FB069 and LGG were able to grow in soy-based products and rapidly reduce their pH as a result of fermentation. The addition of XOS significantly enhanced the acidification rate, viscosity and total cell concentration in fermented soymilk inoculated with W. cibaria FB069. However, the same effect was not observed following inoculation with LGG. Moreover, the synbiotic FSMXW showed higher dextran, folate, GABA and aglycone content. FSMXW inhibited the proliferation of Caco-2 and HCT116 cell lines, by reducing the transcription of MD2, TLR4, MyD88, and NF-jb. Conclusions: The synbiotic soymilk containing XOS and W. cibaria FB069 increase nutrient and functional compounds through fermentation process. Significance and Impact of the Study: Our finding suggests that W. cibaria and XOS can be potentially employed in developing functional foods and health-related products.

The position of teaching equipment in the current digital transformation context is not only a means of active support for the implementation of content and innovation of teaching methods, but also a means of providing new knowledge to students. In order to meet the requirements of innovation in program content and teaching methods, it is necessary to increase the effective use of teaching equipment, especially modern teaching equipment. Teaching equipment is especially important for elementary students because it helps them observe things and phenomena visually, helping students to understand more deeply the content of the lesson. This article evaluates the current situation of teaching equipment management in primary schools in cluster 3, Phu Ly city, Ha Nam province in the context of digital transformation, analyzing strengths and weaknesses, subjective and objective causes from which, 6 measures to effectively manage teaching equipment in primary schools in cluster 3, Phu Ly city, Ha Nam province are proposed in the current digital transformation context.