No abstract

Motivation Recent neural approaches on event extraction from text mainly focus on flat events in general domain, while there are less attempts to detect nested and overlapping events. These existing systems are built on given entities and they depend on external syntactic tools. Results We propose an end-to-end neural nested event extraction model named DeepEventMine that extracts multiple overlapping directed acyclic graph structures from a raw sentence. On the top of the Bidirectional Encoder Representations from Transformers (BERT) model, our model detects nested entities and triggers, roles, nested events and their modifications in an end-to-end manner without any syntactic tools. Our DeepEventMine model achieves the new state-of-the-art performance on seven biomedical nested event extraction tasks. Even when gold entities are unavailable, our model can detect events from raw text with promising performance. Availability and implementation Our codes and models to reproduce the results are available at: https://github.com/aistairc/DeepEventMine Supplementary information Supplementary data are available at Bioinformatics online.

In patients with acromegaly, chronic excess of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) leads to the development of acromegalic cardiomyopathy. Its main features are biventricular hypertrophy, diastolic dysfunction, and in later stages, systolic dysfunction and congestive heart failure. Surgical and/or pharmacological treatment of acromegaly and control of cardiovascular risk factors help reverse some of these pathophysiologic changes and decrease the high risk of cardiovascular complications.

Along with the development of Information Technology, Online Social Networks (OSN) are constantly developing and have become popular media in the world. Besides communication enhancement benefits, OSN have such limitations on rapid spread of false information as rumors, fake news, and contradictory news. False information spread is collectively referred to as misinformation which has significant on social communities. The more sources and topics of misinformation are, the greater the number of users are affected. Therefore, it is necessary to prevent the spread of misinformation with multiple topics within a given period of time. In this paper, we propose a Multiple Topics Linear Threshold model for misinformation diffusion, and define a misinformation blocking problem based on this model that takes account of multiple topics and budget constraint. The problem is to find a set of nodes that minimizes the impact of misinformation at an allowed cost when blocking them from the network. We prove that the problem is NP-hard and the time complexity of the objective function calculation is #P-hard. We also prove that the objective function is monotone and submodular. We propose an approximation algorithm with approximation ratio (1 − 1/ √ e) based on these attributes. For large networks, we propose an extended algorithm by using a tree data structure for quickly updating and calculating the objective function. Experiments conducted on real-world datasets show efficiency and effectiveness of our proposed algorithms in comparison with other state-of-the-art algorithms.

Hypoglycemia is the most common but highly feared side effect of the insulin therapy for patients with Type 1 Diabetes Mellitus (T1DM). Severe episodes of hypoglycemia can lead to unconsciousness, coma, and even death. The variety of hypoglycemic symptoms arises from the activation of the autonomous central nervous system and from reduced cerebral glucose consumption. In this study, electroencephalography (EEG) signals from five T1DM patients during an overnight clamp study were measured and analyzed. By applying a method of feature extraction using Fast Fourier Transform (FFT) and classification using neural networks, we establish that hypoglycemia can be detected non-invasively using EEG signals from only two channels. This paper demonstrates that a significant advantage can be achieved by implementing adaptive training. By adapting the classifier to a previously unseen person, the classification results can be improved from 60% sensitivity and 54% specificity to 75% sensitivity and 67% specificity.