Introduction: Ocular manifestations, such as conjunctivitis, redness, and tearing, were reported in patients with Coronavirus Disease 2019 (COVID-19). Objective: To investigate the level of knowledge, attitude, and practice about the ocular manifestations of COVID-19 and protective eye measures among the general population in the western region of Saudi Arabia. Methods: A cross-sectional study was conducted over two months with 800 participants from the general population and a 39-item online structured validated questionnaire using Google Forms. The collected data were analyzed using the SPSS program version 20 and a P-value <0.05 was considered statistically significant. Results and Discussion: Among the participants (n = 800), 71.9% were females, 50% were highly educated, and 61.8% had moderate incomes. The overall mean total knowledge score was 25.185 ± 3.774, with significant differences regarding age group, gender, and income. Most of the Saudi residents with high monthly incomes, especially females, were knowledgeable regarding the ocular manifestations of COVID-19 (25.0957 ± 3.4311). The average total knowledge, attitude, and practice score was 42.1419 ± 4.833, which was average (medium level), with significant differences regarding age group, gender, and income; a high mean was obtained from the age group >50–60, females, and high-income class. Conclusion: Detailed information about the epidemiology of COVID-19 and an understanding of emerging related health issues, such as ocular manifestations, should be empowered to the public while considering the least knowledgeable groups.