Provided herein are novel carboxylic acid-containing indanyl compounds as S1P5 modulators, pharmaceutical compositions, use of such compounds in treating neurodegenerative diseases, particularly Alzheimer's disease and multiple sclerosis, and processes for preparing such compounds. Important Compound Classes.

Provided herein are monoacylglycerol lipase modulators, pharmaceutical compositions, use of such compounds in treating autism spectrum disorders and processes for preparing such compounds.

Provided herein are novel C-linked isoquinoline amides as LRRK2 inhibitors, their pharmaceutical compositions, the use of such compounds in treating Parkinson’s disease, and processes for preparing such compounds.